First, metabolic activity of a selection of CYP BM3 mutants was screened against AMI and BUS. Metabolic efficiency of the mutant library towards a selection of CYP model substrates, being amitriptyline (AMI), buspirone (BUS), coumarine (COU), dextromethorphan (DEX), diclofenac (DIC) and norethisterone (NET), was investigated. In addition, the concept of utilizing an in-house-developed library of CYP BM3 mutants as a unique biocatalytic synthetic tool to support medicinal chemistry was evaluated. No Downtown service downtown service provided by peak BM2 service.In the present study, the validity of using a cocktail screening method in combination with a chemometrical data mining approach to evaluate metabolic activity and diversity of drug-metabolizing bacterial Cytochrome P450 (CYP) BM3 mutants was investigated.Queens stops began April 2010 last pickup to Manhattan/first dropoff from Manhattan is in Rego Park/Middle Village.Operates to/from Brooklyn via the Queens-Midtown Tunnel.Queens: Woodhaven Boulevard, Cross Bay Boulevardīrooklyn: Linden Boulevard, Ashford Street, Cozine Avenue, Pennsylvania Avenue Operated by Command Bus Company from 1979 until MTA takeover in 2005.īrooklyn: Cortelyou Road, Flatbush Avenue, Avenue H, Avenue M, East 105 Street, Pennsylvania Avenue (downtown trips only)īrooklyn: Cortelyou Road, Ocean Avenue, Avenue X, Emmons Avenueīrooklyn: Cortelyou Road, Ocean Avenue, Nostrand Avenue, Gerritsen Avenue.Manhattan: 5 Avenue, 23 Street, Water Street (SB), Church Street, 23 Street, Madison Avenue (NB)īrooklyn: Cortelyou Road, Ocean Avenue, Avenue K, East 66 Street X38 discontinued in June 2010 due to budget crisis, restored in July 2011.Some peak trips on both routes continue to Sea Gate.X28 terminates at 23 Street or Thomas/Church Streets during rush hours.
X38 operates rush hours only express to 23 Street via FDR Drive.X37 discontinued in June 2010 due to budget crisis, restored in July 2011.X27 terminates at 23 Street or Thomas/Church Streets during rush hours.X37 operates rush hours only express to 23 Street via FDR Drive.Manhattan: Church Street, 6 Avenue, Madison Avenue (NB), 5 Avenue and Broadway (SB) See Manhattan to Staten Island section for more details.Įast 57 Street between Madison and 5 Avenues Weekends only: One stop in Bay Ridge at 86 Street and Gatling Place (from Manhattan) and 86 Street and Dahlgren Place (to Manhattan). Routes BM1 to BM5 are operated by MTA Bus. Routes X27 to X38 are operated by New York City Transit.
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